Monday, 8:15 p.m. ET | ESPN
Matchup rating: 51.5 | Spread: NO -8 (51)
What to watch for: This will be a fun quarterback duel between 20-year veteran Drew Brees and rookie Justin Herbert. But what really defines this matchup, unfortunately, is the overwhelming amount of injuries that have plagued both teams. The Saints could potentially get Michael Thomas back from his Week 1 ankle injury. Meanwhile, the Chargers just lost dynamic running back Austin Ekeler for 4-6 weeks with a hamstring injury. — Mike Triplett
Bold prediction: The Chargers will finally get a win now that Herbert has been named the QB. He will go into the game with confidence, but the Chargers need to stop beating themselves with turnovers. — Shelley Smith
Stat to know: Brees was 5-for-8 for 111 yards and a touchdown on throws of 15-plus yards downfield in Week 4. In the first three games of the season, he had just seven such completions and zero touchdowns.
Injuries: Chargers | Saints
What to know for fantasy: Saints running back Alvin Kamara has been a top-10 running back every week this season and is pacing for 320 touches (current career-high is 275). See Week 5 rankings.
Betting nugget: New Orleans is 6-9 ATS over the past five seasons when favored by seven or more points at home. Read more.
Smith’s pick: Chargers 24, Saints 17
Triplett’s pick: Saints 29, Chargers 23
FPI prediction: NO, 76.2% (by an average of 9.8 points)
Matchup must-reads: Fumbles, injuries put Chargers rookie Kelley in the spotlight … Source: Saints don’t anticipate relocation of MNF game due to hurricane … Saints’ Brees builds connection with Sanders, Smith